Anti-apoptotic block of
Upstream Signaling

The blocked BH3 signal is sequestered near target,
or “Primed” and unique sensitive.

Mitochondrion	Anti-Apoptic Protein	Pro-Apoptic Protein	Activator BH3 Protein	Sensitizor BH3 Protein	BH3 Mimetic Compound

Cells in image stained with mitochondrial dye JC-1 (Life Technologies)